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JUMP DIRECTLY TO SLIDE Autonomic Neuroscience from Bench to Bedside Mentoring Advice How Dysautonomias Teach Us Cardiovascular Continuum Top 7 Lessons From Dysautonomias DBH Deficiency Are Pressor Reflexes Intact? Are Adrenergic Receptors Present? Are Sympathetic Nerves Present? Is Plasma Norepinephrine Present? Catecholamine Synthesis Catecholamine Synthesis Is Plasma Dopamine Present Plasma DA >> NE Catecholamine Synthesis DBH Deficiency Genetics Effect of the Mutation IVS1+2T on DBH Splicing DBH-Deficiency DOPS Therapy DOPS Restores NE To Normal Catechols in DBH Deficiency Top 7 Lessons from Dysautonomias Why is BP low in DBH Deficiency? The TH-Antagonist metyrosine lowers... Top 7 Lessons from Dysautonomias Normal Baroreflex Baroreflex Failure Top 7 Lessons from Dysauntonomias Selective Baroreflex Failure Top 7 Lessons from Dysauntonomias Selective Baroreflex Failure Top 7 Lessons from Dysauntonomias Water and BP in Autonomic Failure Effect of Nn-Nicotinic Blockade... 500 ml Oral vs. Intravenous Fluid Does Oral Water Suppress Sympathetic Activity Water and BP: Many Questions Water in Normal Subjects Water Improves Tolerance of Head-up Tilt Top 7 Lessons from Dysauntonomias Postural Tachycardia Syndrome Postural Tachycardia Syndrome: Many Names Postural Tachycardia Top 7 Lessons from Dysauntonomias Proband with POTS Plasma NE and Sympathetic Activity Tritiated NE Clearance Evidence of NET Deficiency NET Deficiency Identified Coding Variants in the... The A457P Mutant Fails to Demonstrate... How Dysfunctional is A457P? Conclusions Audience Question 1 Audience Question 2 Audience Question 3 Audience Question 4 Audience Question 5 Audience Question 6        synchronize audio with current slide